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放射肿瘤学/随机

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A

   Acute Lymphoblastic Leukemia (ALL)
   Acute Myeloid Leukemia (AML)
   Adolescents, Cancer in
   Adrenocortical Carcinoma
   AIDS-Related Cancers
       Kaposi Sarcoma (Soft Tissue Sarcoma)
       AIDS-Related Lymphoma (Lymphoma)
       Primary CNS Lymphoma (Lymphoma)
   Anal Cancer
   Appendix Cancer - see Gastrointestinal Neuroendocrine Tumors
   Astrocytomas, Childhood (Brain Cancer)
   Atypical Teratoid/Rhabdoid Tumor, Childhood, Central Nervous System (Brain Cancer)

B

   Basal Cell Carcinoma of the Skin - see Skin Cancer
   Bile Duct Cancer
   Bladder Cancer
   Bone Cancer (includes Ewing Sarcoma and Osteosarcoma and Malignant Fibrous Histiocytoma)
   Brain Tumors
   Breast Cancer
   Bronchial Tumors (Lung Cancer)
   Burkitt Lymphoma - see Non-Hodgkin Lymphoma

C

   Carcinoma of Unknown Primary
   Central Nervous System
       Atypical Teratoid/Rhabdoid Tumor, Childhood (Brain Cancer)
       Medulloblastoma and Other CNS Embryonal Tumors, Childhood (Brain Cancer)
       Germ Cell Tumor, Childhood (Brain Cancer)
       Primary CNS Lymphoma
   Cervical Cancer
   Childhood Cancers
   Childhood Cardiac Tumors Treatment
   Cancers of Childhood, Rare
   Cholangiocarcinoma - see Bile Duct Cancer
   Chordoma, Childhood (Bone Cancer)
   Chronic Lymphocytic Leukemia (CLL)
   Chronic Myelogenous Leukemia (CML)
   Chronic Myeloproliferative Neoplasms
   Colorectal Cancer
   Craniopharyngioma, Childhood (Brain Cancer)
   Cutaneous T-Cell Lymphoma - see Lymphoma (Mycosis Fungoides and Sézary Syndrome)

D

   Ductal Carcinoma In Situ (DCIS) - see Breast Cancer

E

   Embryonal Tumors, Medulloblastoma and Other Central Nervous System, Childhood (Brain Cancer)
   Endometrial Cancer (Uterine Cancer)
   Ependymoma, Childhood (Brain Cancer)
   Esophageal Cancer
   Esthesioneuroblastoma (Head and Neck Cancer)
   Ewing Sarcoma (Bone Cancer)
   Extracranial Germ Cell Tumor, Childhood
   Extragonadal Germ Cell Tumor
   Eye Cancer
       Intraocular Melanoma
       Retinoblastoma

F

   Fallopian Tube Cancer

G

   Gallbladder Cancer
   Gastric (Stomach) Cancer
   Gastrointestinal Neuroendocrine Tumors
   Gastrointestinal Stromal Tumors (GIST) (Soft Tissue Sarcoma)
   Germ Cell Tumors
       Childhood Central Nervous System Germ Cell Tumors (Brain Cancer)
       Childhood Extracranial Germ Cell Tumors
       Extragonadal Germ Cell Tumors
       Ovarian Germ Cell Tumors
       Testicular Cancer
   Gestational Trophoblastic Disease

H

   Hairy Cell Leukemia
   Head and Neck Cancer
   Heart Tumors, Childhood
   Hepatocellular (Liver) Cancer
   Histiocytosis, Langerhans Cell
   Hodgkin Lymphoma
   Hypopharyngeal Cancer (Head and Neck Cancer)

I

   Intraocular Melanoma
   Islet Cell Tumors, Pancreatic Neuroendocrine Tumors

K

   Kaposi Sarcoma (Soft Tissue Sarcoma)
   Kidney (Renal Cell) Cancer

L

   Langerhans Cell Histiocytosis
   Laryngeal Cancer (Head and Neck Cancer)
   Leukemia
   Lip and Oral Cavity Cancer (Head and Neck Cancer)
   Liver Cancer
   Lung Cancer (Non-Small Cell, Small Cell, Pleuropulmonary Blastoma, Pulmonary Inflammatory Myofibroblastic Tumor, and Tracheobronchial Tumor)
   Lymphoma 

M

   Male Breast Cancer
   Melanoma
   Melanoma, Intraocular (Eye)
   Merkel Cell Carcinoma (Skin Cancer)
   Mesothelioma, Malignant
   Metastatic Cancer
   Metastatic Squamous Neck Cancer with Occult Primary (Head and Neck Cancer)
   Midline Tract Carcinoma With NUT Gene Changes
   Mouth Cancer (Head and Neck Cancer)
   Multiple Endocrine Neoplasia Syndromes
   Multiple Myeloma/Plasma Cell Neoplasms
   Mycosis Fungoides (Lymphoma)
   Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
   Myelogenous Leukemia, Chronic (CML)
   Myeloid Leukemia, Acute (AML)
   Myeloproliferative Neoplasms, Chronic

N

   Nasal Cavity and Paranasal Sinus Cancer (Head and Neck Cancer)
   Nasopharyngeal Cancer (Head and Neck Cancer)
   Neuroblastoma
   Neuroendocrine Tumors (Gastrointestinal)
   Non-Hodgkin Lymphoma
   Non-Small Cell Lung Cancer

O

   Oral Cancer, Lip and Oral Cavity Cancer and Oropharyngeal Cancer (Head and Neck Cancer)
   Osteosarcoma and Undifferentiated Pleomorphic Sarcoma of Bone Treatment
   Ovarian Cancer

P

   Pancreatic Cancer
   Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)
   Papillomatosis (Childhood Laryngeal)
   Paraganglioma
   Paranasal Sinus and Nasal Cavity Cancer (Head and Neck Cancer)
   Parathyroid Cancer
   Penile Cancer
   Pharyngeal Cancer (Head and Neck Cancer)
   Pheochromocytoma
   Pituitary Tumor
   Plasma Cell Neoplasm/Multiple Myeloma
   Pleuropulmonary Blastoma (Lung Cancer)
   Pregnancy and Breast Cancer
   Primary Central Nervous System (CNS) Lymphoma
   Primary Peritoneal Cancer
   Prostate Cancer
   Pulmonary Inflammatory Myofibroblastic Tumor (Lung Cancer)

R

   Rare Cancers of Childhood
   Rectal Cancer
   Recurrent Cancer
   Renal Cell (Kidney) Cancer
   Retinoblastoma
   Rhabdomyosarcoma, Childhood (Soft Tissue Sarcoma)

S

   Salivary Gland Cancer (Head and Neck Cancer)
   Sarcoma
       Childhood Rhabdomyosarcoma (Soft Tissue Sarcoma)
       Childhood Vascular Tumors (Soft Tissue Sarcoma)
       Ewing Sarcoma (Bone Cancer)
       Kaposi Sarcoma (Soft Tissue Sarcoma)
       Osteosarcoma (Bone Cancer)
       Soft Tissue Sarcoma
       Uterine Sarcoma
   Sézary Syndrome (Lymphoma)
   Skin Cancer
   Small Cell Lung Cancer
   Small Intestine Cancer
   Soft Tissue Sarcoma
   Squamous Cell Carcinoma of the Skin - see Skin Cancer
   Squamous Neck Cancer with Occult Primary, Metastatic (Head and Neck Cancer)
   Stomach (Gastric) Cancer

T

   T-Cell Lymphoma, Cutaneous - see Lymphoma (Mycosis Fungoides and Sèzary Syndrome)
   Testicular Cancer
   Throat Cancer (Head and Neck Cancer)
       Nasopharyngeal Cancer
       Oropharyngeal Cancer
       Hypopharyngeal Cancer
   Thymoma and Thymic Carcinoma
   Thyroid Cancer
   Tracheobronchial Tumors (Lung Cancer)
   Transitional Cell Cancer of the Renal Pelvis and Ureter (Kidney (Renal Cell) Cancer)

U

   Unknown Primary, Carcinoma of
   Ureter and Renal Pelvis, Transitional Cell Cancer (Kidney (Renal Cell) Cancer
   Urethral Cancer
   Uterine Cancer, Endometrial
   Uterine Sarcoma

V

   Vaginal Cancer
   Vascular Tumors (Soft Tissue Sarcoma)
   Vulvar Cancer

W

   Wilms Tumor and Other Childhood Kidney Tumors

Y

   Young Adults, Cancer in

随机证据

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文献综述

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  • 肯塔基州;2009 PMID 19111269 -- "需要对创新放射治疗技术进行随机前瞻性试验。" (Halperin EC, J Am Coll Radiol. 2009 年 1 月;6(1):33-7.)
    • "可以确定应在广泛临床实践中引入之前,需要在随机前瞻性临床试验中证明其效益的创新。"
  • 加拿大国家癌症研究所;2008 (1975–2004) PMID 18955452 -- "三十年来肿瘤学随机对照试验的演变。" (Booth CM, J Clin Oncol. 2008 年 10 月 27 日。[提前发表])
    • 回顾了 321 份评估乳腺癌、CRC 和 NSCLC 系统治疗的 RCT 报告。
    • 结果:RCT 的数量和规模大幅增加。营利性赞助大幅增加(4% 至 57%,SS)。效应量保持稳定,但作者更有可能强烈支持实验组(SS)。对实验组的支持与行业赞助密切相关。
  • 威斯康星州;2008 PMID 18237799 -- "健康技术评估中的随机对照试验:过度吗?还是姗姗来迟?" (Bentzen SM, Radiother Oncol. 2008 年 1 月 29 日 [提前发表])
  • 牛津大学;2007 PMID 17303884 -- "何时随机试验不必要?从噪声中识别信号。" (Glasziou P, BMJ. 2007 年 2 月 17 日;334(7589):349-51.)
  • RTOG;2005 (1968–2002) PMID 15728168 -- "放射肿瘤学新疗法的评价:它们比标准疗法好吗?" (Soares HP, JAMA. 2005 年 2 月 23 日;293(8):970-8.)
    • 回顾了所有已完成的 III 期 RTOG 试验。57 项试验,12734 名患者
    • 结果:干预组相对于标准组的生存 OR 为 1.01 (NS)。只有 10% 显著优于标准组,88% 结论不确定。
    • 毒性:干预组与治疗相关的死亡率 OR 为 1.76,高于标准组 (SS)。
    • 结论:无法提前预测个别试验的结果。
  • COG;2005 (1955–1997) PMID 16299015 -- "儿童癌症的实验治疗是否优于既定治疗?对儿童肿瘤学组随机对照试验的观察性研究。" (Kumar A, BMJ. 2005 年 12 月 3 日;331(7528):1295. 2005 年 11 月 18 日提前发表)
    • 回顾了已完成的 III 期试验。126 项试验,36567 名患者。
    • 结果:生存 OR 为 0.96 (NS)。
    • 结论:儿童癌症的新治疗方法与既定治疗方法相比,同样有可能效力较低,也有可能效力较高。
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